Publications
Kwok HS*, Morriss JW*, Hu CXY*, Iram I, Myung Y, Siegenfeld AP, Waterbury AL, Yeo MJR, Lee C, Camp S, Iqbal S, Liau BB. (2025) Base editing charts a sequence-function atlas of Polycomb Repressive Complex 2 at amino acid resolution. Submitted.
Kwok HS*, Freedy AM*, Siegenfeld AP, Morriss JW, Waterbury AL, Kissler SM, Liau BB. (2023) Drug addiction mutations unveil a methylation ceiling in EZH2-mutant lymphoma. Nature Chemical Biology. 19, 1105-1115. doi: 10.1038/s41589-023-01299-1.
Featured in the Nature Chemical Biology News & Views article (Reich & Lewis, Nat Chem Biol. 2023)
Featured in the Trends in Pharmacological Sciences Spotlight article (Barka et al., Trends Pharmacol Sci. 2023)
Waterbury AL*, Kwok HS*, Lee C*, Narducci D, Freedy AM, Su C, Raval S, Reiter A, Hawkins W, Lee K, Li J, Hoenig SM, Vinyard ME, Cole PA, Hansen AS, Carr SA, Papanastasiou M, Liau BB. (2024) An autoinhibitory switch of the LSD1 disordered region controls enhancer silencing. Molecular Cell, 84, 2238-2254. doi: 10.1016/j.molcel.2024.05.017
Roh H*, Shen SP*, Hu Y*, Kwok HS, Siegenfeld AP, Lee C, Zepeda M, Guo C, Roseman SA, Sankaran VG, Buenrostro JD, Liau BB. (2025) Coupling CRISPR scanning with targeted chromatin accessibility profiling using a double-stranded DNA deaminase. Nature Methods 22, 2083-2093. doi.org/10.1038/s41592-025-02811-2
Featured in the Nature Research Highlight article (Marchal, Nature Biotechnology 2025)
Yeo MJR*, Zhang O*, Xie X*, Nam E*, Payne NC, Gosavi PM, Kwok HS, Iram I, Lee C, Li J, Chen N, Nguyen K, Jiang H, Wang ZA, Lee K, Mao H, Harry SA, Barakat I, Takahashi M, Waterbury AL, Barone M, Mattevi A, Carr SA, Udeshi ND, Bar-Peled L, Cole PA, Mazitschek R, Liau BB.#, Zheng N.# (2025) UM171 glues asymmetric CRL3–HDAC1/2 assembly to degrade CoREST corepressors. Nature, 639, 232–240. doi.org/10.1038/s41586-024-08532-4 (#Co-corresponding authors)
Xie X*, Zhang O*, Yeo MJR*, Lee C*, Tao R, Harry SA, Payne NC, Nam E, Paul L, Li Y, Kwok HS, Jiang H, Mao H, Hadley JL, Lin H, Batts M, Gosavi PM, D’Angiolella V, Cole PA, Mazitschek R, Northcott PA, Zheng N#, Liau BB#. (2025) Converging mechanism of UM171 and KBTBD4 neomorphic cancer mutations. Nature, 639, 241–249. doi.org/10.1038/s41586-024-08533-3 (#Co-corresponding authors)
Featured in the Nature News & Views article (Bushman & Potts, Nature 2025)
Ngan KC, Hoenig SM, Kwok HS, Lue NZ, Gosavi PM, Tanner DA, Garcia EM, Lee C, Liau BB. (2023) Activity-based CRISPR scanning uncovers allostery in DNA methylation maintenance machinery. Elife 12, e80640. doi: 10.7554/eLife.80640
Barta PA, Garnar-Wortzel L, Bishop TR, Hayward RE, Hargis IM, Shaum JB, Kwok HS, Liau BB, Cravatt BF, Erb MA. (2025) A chemical-genetic interaction between PAF1 and ENL/AF9 YEATS inhibition. RSC Chemical Biology (in press). doi: 10.1039/D5CB00233H
Merz ML*, Shoba VM*, Pergu R*, Severance ZC*, Dhanushka N, Godage PM, Deb A, Kwok HS, Singh P, Singh S, Allen JB, Tian W, Gosavi PM, Chauhary SK, Anokhina V, Weisberg EL, Payne NC, He Y, Dhaliwal R, Osadchey R, Shekhar M, Mazitschek R, Rees MG, Roth JA, Cui Q, Griffin JD, Liau BB, Choudhary A. (2025) bioRxiv. doi: 10.1101/2025.06.13.659082.
Other contributions (prior to 2020)
Kwok HS#, Vargas-Rodriguez O, Melnikov SV, Söll D. (2019) Engineered aminoacyl-tRNA synthetases with improved selectivity toward noncanonical amino acids. ACS Chemical Biology, 14(4), 603–612. doi: 10.1021/acschembio.9b00088 (#Sole corresponding author)
Melnikov SV, Stevens DL, Fu X, Kwok HS, Zhang JT, Shen Y, Sabina J, Lee K, Lee H, Söll D. (2020) Exploiting evolutionary trade-offs for post-treatment management of drug-resistant populations. Proceedings of the National Academy of Sciences, 117(30), 17924–17931. doi.org/10.1073/pnas.2003132117
Melnikov S, Kwok HS, Manakongtreecheep K, Elzen A, van den Thoreen CC, Söll D. (2019) Archaeal Ribosomal Proteins Possess Nuclear Localization Signal-Type Motifs: Implications for the Origin of the Cell Nucleus. Molecular Biology and Evolution, 37(1), 124–133. doi.org/10.1093/molbev/msz207
Numata A*, Kwok HS*, Zhou QL*, Li J, Tirado-Magallanes R, Angarica VE, Hannah R, Park J, Wang CQ, Krishnan, V, Rajagopalan D, Zhang Y, Zhou S, Welner RS, Osato M, Jha S, Bohlander SK, Göttgens B, Yang H, Benoukraf T, Lough JW, Bararia D, Tenen DG. (2020) Lysine acetyltransferase Tip60 is required for hematopoietic stem cell maintenance. Blood, 136(15), 1735–1747. doi: 10.1182/blood.2019001279
Numata A*, Kwok HS*, Kawasaki A, Li J, Zhou QL, Kerry J, Benoukraf T, Bararia D, Li F, Ballabio E, Tapia M, Deshpande AJ, Welner RS, Delwel R, Yang H, Milne TA, Taneja R, Tenen DG. (2018) The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia. Nature Communications, 9(1), 1622. doi: 10.1038/s41467-018-03854-0
Bararia D*, Kwok HS*, Welner RS, Numata A, Sárosi MB, Yang H, Wee S, Tschuri S, Ray D, Weigert O, Levantini E, Ebralidze AK, Gunaratne J, Tenen DG. (2016) Acetylation of C/EBPα inhibits its granulopoietic function. Nature Communications, 7(1), 10968. doi: 10.1038/ncomms1096
Hong H, An O, Chan TH, Ng VH, Kwok HS, Lin JS, Qi L, Han J, Tay DJ, Tang SJ, Yang H, Song Y, Bellido-Molias F, Tenen DG, Chen L. (2018) Bidirectional regulation of adenosine-to-inosine (A-to-I) RNA editing by DEAH box helicase 9 (DHX9) in cancer. Nucleic Acids Research, 46(15), 7953–7969. doi.org/10.1093/nar/gky396
Rajagopalan D, Pandey AK, Xiuzhen MC, Lee KK, Hora S, Zhang Y, Chua BH, Kwok HS, Bhatia SS, Deng LW, Tenen DG, Kappei D, Jha S. (2017) TIP60 represses telomerase expression by inhibiting Sp1 binding to the TERT promoter. PLOS Pathogens, 13(10), e1006681. doi.org/10.1371/journal.ppat.1006681
Lew QJ, Chu KL, Chia YL, Soo B, Ho JP, Ng CH, Kwok HS, Chiang CM, Chang Y, Chao SH. (2015) GCN5 inhibits XBP-1S-mediated transcription by antagonizing PCAF action. Oncotarget, 6(1), 271–287. doi.org/10.18632/oncotarget.2773
Leong DT, Lim J, Goh X, Pratap J, Pereira BP, Kwok HS, Nathan SS, Dobson JR, Lian JB, Ito Y, Voorhoeve PM, Stein GS, Salto-Tellez M, Cool SM, van Wijnen AJ. (2010) Cancer-related ectopic expression of the bone-related transcription factor RUNX2 in non-osseous metastatic tumor cells is linked to cell proliferation and motility. Breast Cancer Research: BCR, 12(5), R89. doi.org/10.1186/bcr2762