We study how chromatin regulators and histone proteins control gene regulation, and how disease-associated mutations disrupt these processes in human diseases.

We integrate functional genomics and mechanistic approaches to trace effects of genetic variation from sequence → mechanism → phenotype, with the goal of identifying actionable cancer vulnerabilities.

We pursue this through a systematic framework:

• Discovery: Identify mutations in chromatin regulators that have functional and cellular impact

• Mechanism: Define how prioritized mutations alter chromatin function at the molecular level.

• Translation: Connect molecular mechanisms to cellular phenotypes and therapeutic opportunities.

A major focus of the lab is on mutations in lysine methyltransferase complexes and histone proteins that are recurrently mutated in cancer.